Tuesday, September 26, 2023
2023: 1930 Chronology: Appendix 28: Dolores Shockley, The First African American Woman to Receive a Doctorate in Pharmacology
Saturday, September 23, 2023
2023: 1930 Chronology: Appendix 27: Faith Ringgold, Painter, Sculptor, Author, Performance Artist, and Civil Rights Activist
Appendix 27
Faith Ringgold
Painter, Sculptor, Author, Performance Artist
and
Civil Rights Activist
Faith Ringgold (b. October 8, 1930, New York, New York - d. April 13, 2024, Englewood, New Jersey), was an artist and author who became famous for innovative, quilts that communicate her political beliefs.
Friday, September 22, 2023
2023: 1930 Chronology: Appendix 26: Auburn "Pat" Hare, a Memphis Electric Blues Guitarist and Heavy Metal Pioneer
Appendix 26
Auburn "Pat" Hare
Memphis Electric Blues Guitarist
and
Heavy Metal Pioneer
Auburn "Pat" Hare (b. December 20, 1930, Cherry Valley, Arkansas - September 26, 1980, Saint Paul, Minnesota) was a Memphis electric blues guitarist and singer. His heavily distorted, power chord-driven electric guitar performances in the early 1950s are considered an important precursor of heavy metal music. His guitar work with Little Junior's Blue Flames had a major influence on the rockabilly style, and his guitar playing on blues records by artists such as Muddy Waters was influential among 1960s British Invasion blues rock bands such as the Rolling Stones and the Yardbirds.
Hare, an African American, was born in Cherry Valley, Arkansas. He recorded at the Sun Studio in Memphis, Tennessee, serving as a sideman for Howlin' Wolf, James Cotton, Muddy Waters, Bobby Bland and other artists. Hare was one of the first guitarists to purposely use the effects of distortion in his playing.
In 1951, Hare joined a blues band formed by Junior Parker, called Little Junior's Blue Flames. He played the electric guitar solo on "Love My Baby" (1953), which later inspired the rockabilly style. One of their biggest hits was "Next Time You See Me", which in 1957 reached number 5 on the Billboard R&B chart and number 74 on the Billboard Hot 100 pop chart.
Hare's guitar solo on James Cotton's electric blues record "Cotton Crop Blues" (1954) was the first recorded use of heavily distorted power chords, later an element of heavy metal music. The other side of the single was "Hold Me in Your Arms"; both songs featured a guitar sound so overdriven that with the historical distance of several decades, it now sounds like a direct line to the coarse, distorted tones favored by modern rock players.
Hare was reported to have been introverted when sober (once married to Dorothy Mae Good, with whom he had a son and two daughters), but he had a serious problem with alcohol abuse. Shortly after the "Cotton Crop Blues" recording, he recorded a version of the early 1940s Doctor Clayton song "I'm Gonna Murder My Baby" on May 14, 1954, which has since been released on the 1990 Rhino Records compilation album Blue Flames: A Sun Blues Collection. The record also features power chords, which remains most fundamental in modern rock as the basic structure for riff-building in heavy metal bands.
According to the album liner notes, "I'm Gonna Murder My Baby" is "doubly morbid because he did just that". In December 1963, Hare shot his girlfriend dead in Minneapolis and also shot a policeman who came to investigate. At the time of his arrest, he was playing in the blues band of Muddy Waters.
Hare pleaded guilty to murder and spent the last 16 years of his life in prison, where he formed a band named Sounds Incarcerated. He developed lung cancer in prison and died in 1980 in Saint Paul, Minnesota.
Tuesday, September 19, 2023
2023: 1930 Chronology: Appendix 25: Tu Youyou, 2015 Nobel Prize Recipient in Medicine for Development of Anti-Malarial Drug
Appendix 25
Tu Youyou
2015 Nobel Prize Recipient in Medicine
for
Development of Anti-Malarial Drugs
Tu Youyou (b. December 30, 1930, Ningbo, Zhejiang, China) was a Chinese pharmaceutical chemist and malariologist. She discovered artemisinin (also known as qinghaosu) and dihydroartemisinin, used to treat malaria, a breakthrough in twentieth-century tropical medicine, saving millions of lives in South China, Southeast Asia, South America, and Africa.
For her work, Tu received the 2011 Lasker Award in clinical medicine and the 2015 Nobel Prize in Physiology or Medicine jointly with William C. Campbell and Satoshi Omura. Tu was the first Chinese Nobel laureate in physiology or medicine and the first female citizen of the People's Republic of China to receive a Nobel Prize in any category. She was also the first Chinese person to receive the Lasker Award. Tu was born, educated and carried out her research exclusively in China.
Tu was born in Ningbo, Zhejiang, China, on December 30, 1930. She attended Xiaoshi Middle School for junior high school and the first year of high school, before transferring to Ningbo Middle School in 1948. A tuberculosis infection interrupted her high school education but inspired her to go into medical research. From 1951 to 1955, she attended Peking University Medical School / Beijing Medical College. In 1955, Tu graduated from Beijing Medical University School of Pharmacy and continued her research on Chinese herbal medicine in the China Academy of Chinese Medical Sciences. Tu studied at the Department of Pharmaceutical Sciences and graduated in 1955. Later Tu was trained for two and a half years in traditional Chinese medicine.
After graduation, Tu worked at the Academy of Traditional Chinese Medicine (now the China Academy of Traditional Chinese Medical Sciences) in Beijing.
Tu carried on her work in the 1960s and 70s, including during China's Cultural Revolution.
During her early years in research, Tu studied Lobelia chinensis, a traditional Chinese medicine believed to be useful for treating schistosomiasis, caused by trematodes which infect the urinary tract or the intestines, which was widespread in the first half of the 20th century in South China.
In 1967, during the Vietnam War, President Ho Chi Minh of North Vietnam asked Chinese Premier Zhou Enlai for help in developing a malaria treatment for his soldiers trooping down the Ho Chi Minh trail, where a majority came down with a form of malaria which is resistant to chloroquine. Because malaria was also a major cause of death in China's southern provinces, especially Guangdong and Guangxi, Zhou Enlai convinced Mao Zedong to set up a secret drug discovery project named Project 523 after its starting date, May 23, 1967.
In early 1969, Tu was appointed head of the Project 523 research group at her institute. Tu was initially sent to Hainan, where she studied patients who had been infected with the disease.
Scientists worldwide had screened over 240,000 compounds without success. In 1969, Tu, then 39 years old, had an idea of screening Chinese herbs. She first investigated the Chinese medical classics in history, visiting practitioners of traditional Chinese medicine all over the country on her own. She gathered her findings in a notebook called A Collection of Single Practical Prescriptions for Anti-Malaria. Her notebook summarized 640 prescriptions. By 1971, her team had screened over 2,000 traditional Chinese recipes and made 380 herbal extracts, from some 200 herbs, which were tested on mice.
One compound was effective, sweet wormwood (Artemisia annua), which was used for "intermittent fevers," a hallmark of malaria. As Tu also presented at the project seminar, its preparation was described in a 1,600-year-old text, in a recipe titled, "Emergency Prescriptions Kept Up One's Sleeve". At first, it was ineffective because they extracted it with traditional boiling water. Tu discovered that a low-temperature extraction process could be used to isolate an effective anti-malarial substance from the plant. Tu was also influenced by a traditional Chinese herbal medicine source, The Handbook of Prescriptions for Emergency Treatments, written in 340 by Ge Hong, which states that this herb should be steeped in cold water. This book instructed the reader to immerse a handful of qinghao in the equivalent of 0.4 liters of water, wring out the juice, and drink it all. After rereading the recipe, Tu realized the hot water had already damaged the active ingredient in the plant. Therefore, she proposed a method using low-temperature ether to extract the effective compound instead. Animal tests showed it was completely effective in mice and monkeys.
In 1972, Tu and her colleagues obtained the pure substance and named it qinghaosu, or artemisinin in English. This substance saved millions of lives, especially in the developing world. Tu also studied the chemical structure and pharmacology of artemisinin. Tu's group first determined the chemical structure of artemisinin. In 1973, Tu was attempting to confirm the carbonyl group in the artemisinin molecule when she accidentally synthesized dihydroartemisinin.
Tu volunteered to be the first human test subject. It was safe, so she conducted successful clinical trials with human patients. Her work was published anonymously in 1977. In 1981, she presented the findings related to artemisinin at a meeting with the World Health Organization.
For her work on malaria, Tu Youyou was awarded the Nobel Prize in Medicine on October 5, 2015.
Tu Youyou was promoted to Researcher, the highest researcher rank in mainland China equivalent to the academic rank of a full professor in 1980, shortly after the beginning of the Chinese economic reform in 1978. In 2001, she was promoted to academic advisor for doctoral candidates. As of 2023, she was the chief scientist of the China Academy of Chinese Medical Sciences.
Before 2011, Tu Youyou had been obscure for decades, and was almost completely forgotten by the Chinese people. However, after receiving the Lasker Prize and the Nobel Prize, today Tu is regarded as the "Three-Without Scientist"[ – a scientist with no postgraduate degree (there was no postgraduate education then in China), no study or research experience abroad, and no membership in either of the Chinese national academies, the Chinese Academy of Sciences and the Chinese Academy of Engineering. Tu is also now regarded as a representative figure of the first generation of Chinese medical workers after the establishment of the People's Republic of China in 1949.
Wednesday, September 13, 2023
2023: 1930 Chronology: Appendix 24: Lorraine Hansberry, African American Playwright Who Wrote "A Raisin in the Sun"
Appendix 24
Lorraine Hansberry
African American Playwright
Who Wrote
"A Raisin in the Sun"
Lorraine Vivian Hansberry (b. May 19, 1930, Chicago, Illinois – d. January 12, 1965, New York City, New York) was an American playwright and writer. Hansberry inspired Nina Simone's song "To Be Young, Gifted and Black".
Tuesday, September 12, 2023
2023: 1930 Chronology: Appendix 23: Jessie Isabelle Price, The Duck Doctor
Jessie Isabelle Price (b. January 1, 1930, Montrose, Pennsylvania – November 12, 2015, Madison, Wisconsin) was a veterinary microbiologist. She isolated and reproduced the cause of the most common life-threatening disease in duck farming in the 1950s and developed vaccines for this and other avian diseases. A graduate of Cornell University, where she earned a PhD (1959), she worked first at the Cornell Duck Research Laboratory and later at the United States Geological Survey (USGS) National Wildlife Health Center. She served as chair of the Predoctoral Minority Fellowship Ad Hoc Review Committee of the American Society for Microbiology (ASM), and as president of Graduate Women in Science.
Jessie Price was born in Montrose, Pennsylvania. Her mother, Teresa Price, raised her daughter on her own in difficult financial circumstances. Price was the only African-American in her class, at a school where there were only two other Black students. After graduating from Montrose High School, she was accepted into Cornell University, moving with her mother to Ithaca to take advanced high classes in mathematics and English for a year. Tuition fees were waived because of her New York residency and grades. She wanted to be a physician, but could not because of the cost. Price received a Bachelor of Science in the College of Agriculture in 1953.
Her mentor, Dorsey Bruner, recommended post-graduate studies, but finances prohibited it. Price worked for three years as a laboratory technician in the Poultry Disease Research Farm in the Veterinary College at Cornell to save for further study. She obtained research assistant support for 1956 to 1959, receiving a Masters in 1958, and a doctorate in 1959, supervised by Bruner. Her Master's thesis was "Morphological and Cultural Studies of Pleuropneumonia-like Organisms and Their Variants Isolated from Chickens".
For her doctoral dissertation, Price isolated and reproduced the bacterium, Pasteurella anatipestifer, in white pekin ("Long Island") ducklings infected with a disease that was a major killer among duck farmers at that time. Her dissertation was published by Cornell University in 1959.
After her PhD, Price joined the Cornell Duck Research Laboratory, where she worked from 1959 to 1977, teaching at Long Island University, where she became an adjunct professor. She worked on developing a vaccine, undertaking trials of mixed flocks of vaccinated and unvaccinated ducklings, working every day, and conducting daily autopsies. In 1964, Ebony magazine featured Price and her work in an extensive photo-essay describing and showing her work on vaccine development, in the Duck Research Laboratory and on the farm. Price described the heavy workload, made more onerous by the four-mile distance between the laboratory and farm where the flocks of ducklings were managed.
Long Island "New Duck Disease" is an infectious disease affecting primarily ducklings, with a high mortality rate. In 1956, the United States Department of Agriculture (USDA) reported that it was "the most important disease problem of the duck industry", with losses of up to 75% of populations. For her doctoral work, Price isolated and reproduced Pasteurella anatipestifer, an essential step for vaccine development.
While at the Cornell Duck Research Laboratory, she began working on vaccine development for Pasteurella anatipestifer for white pekin ducks, which she would continue in avian cholera and tuberculosis (TB) for various species through her career. Some of the vaccines were commercially developed. She worked with national and international colleagues, publishing on Pasteurella anatipestifer in pheasants, medication for bacterial infections in ducklings, Pasteurella multocida in Nebraska wetlands and in snow geese.
In 1966, Price was awarded a National Science Foundation travel grant to present her findings at the International Congress for Microbiology in Moscow. By 1974, she had developed an injectable vaccine and was moving on to studying oral vaccination. She moved to the USGS National Wildlife Health Center in Madison, Wisconsin in 1977, and the study of environmental contaminants and diseases in wildlife, especially water fowl.
Her professional activities included serving as chair of the Predoctoral Minority Fellowship Ad Hoc Review Committee of the American Society for Microbiology (ASM), as well as its Summer Research Fellowship and Travel Award Program. Price was also a member of the ASM's Committee on the Status of Minority Microbiologists and its Committee on the Status of Women Microbiologists. She was also active in Graduate Women in Science (also called Sigma Delta Epsilon), serving as national president from 1974 to 1975, after being national second vice-president (1972-1973), as well as on the national board of directors (1976-1980).
Price was a dog-lover and breeder, with a prize-winning Corgi in the 1960s. Her other favorite pastimes were photography, music, and travel.
Price died of Lewy body dementia on November 12, 2015, in Madison, Wisconsin, and was buried in Quoque Cemetery on Long Island.
Wednesday, September 6, 2023
2023: 1930 Chronology: Appendix 22: Willie Thrower, The First African American National Football League Quarterback
APPENDIX 22
WILLIE THROWER
THE FIRST AFRICAN AMERICAN
NATIONAL FOOTBALL LEAGUE
QUARTERBACK
Willie Lee Thrower (b. March 22, 1930, New Kensington, Pennsylvania – d. February 20, 2002, New Kensington, Pennsylvania) was an American football quarterback. Born near Pittsburgh in New Kensington, Pennsylvania, Thrower was known as "Mitts" for his large hands and arm strength compared to his 5'11" frame. He was known to be able to toss a football 70 yards. Thrower was part of the 1952 Michigan State Spartans who won the national championship. He became the first African American to appear at the quarterback position in the National Football League (NFL), playing for the Chicago Bears in 1953.